IONIS PHARMACEUTICALS INC

Pharmaceutical Preparations·CARLSBAD, CA·FY end 12/31·CIK 874015

CEO Pay Ratio

44:1

Brett P. Monia

CEO Total Comp

$18.0K

Brett P. Monia

Median Employee

$304,680

Revenue

$203.3M

FY 2025

Net Income

-$229.4M

FY 2025

Free Cash Flow

-$320.0M

FY 2025

Net Margin

-112.8%

Insider Net (180d)

-$57.5M

0 buys / 44 sales

CEO Pay Accountability

CEO comp as % of net income

-0.01%

For every $1,000 of profit, $-0.08 flows to the CEO.

CEO comp as % of buybacks

—

No buyback data for the most recent fiscal year.

5-year history · USD

Metric	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021	Trend
Revenue	$203.3M	$226.6M	$324.5M	$151.9M	$440.0M
Gross Profit	—	—	—	—	—	—
Operating Income	-$214.5M	-$110.8M	-$6.1M	-$208.0M	$220.6M
Net Income	-$229.4M	-$104.3M	-$9.3M	-$269.7M	$224.6M
Operating CF	-$268.6M	-$500.9M	-$307.5M	-$274.4M	$30.8M
Capex	$51.4M	$45.3M	$23.8M	$15.7M	$12.0M
Free Cash Flow	-$320.0M	-$546.2M	-$331.3M	-$290.1M	$18.8M
Buybacks	—	—	—	$0	$0
Dividends	—	—	—	—	—	—

Gross Margin	—	—	—	—	—	—
Operating Margin	-105.5%	-48.9%	-1.9%	-137.0%	50.1%
Net Margin	-112.8%	-46.1%	-2.9%	-177.6%	51.0%
FCF Margin	-157.4%	-241.1%	-102.1%	-191.0%	4.3%
R&D / Revenue	450.3%	—	—	—	145.0%
Effective Tax	-0.5%	1.3%	-9.7%	-4.5%	1.9%
Debt / Equity	6.42	4.17	6.59	4.14	—
Buybacks / FCF	—	—	—	0.0%	0.0%

FY 2025

Executive	Salary	Stock	Options	Bonus / Inc.	Other	Total
Brian BirchlerEVP, Corporate and Development Operations	$580.2K	$1.1M	$536.9K	$617.3K	$366.8K	$48.0K
Richard S. GearyEVP, Chief Development Officer	$622.1K	$1.1M	$536.9K	$661.9K	$366.8K	$47.8K
Elizabeth L. HougenEVP, Finance and Chief Financial Officer	$729.8K	$1.5M	$756.6K	$831.9K	$516.8K	$43.0K
Brett P. MoniaChief Executive Officer	$1.1M	$4.3M	$4.1M	$2.4M	$1.4M	$18.0K
Eric SwayzeEVP, Research	$589.0K	$1.1M	$536.9K	$626.7K	$366.8K	$18.0K
Patrick R. O’NeilEVP, Chief Legal Officer and General Counsel	$611.8K	$1.1M	$536.9K	$581.2K	$366.8K	$18.0K