IONIS PHARMACEUTICALS INC

Pharmaceutical Preparations·CARLSBAD, CA·FY end 12/31·CIK 874015

Named Executive Officers

FY 2025

Executive	Salary	Stock	Options	Bonus / Inc.	Other	Total
Brian BirchlerEVP, Corporate and Development Operations	$580.2K	$1.1M	$536.9K	$617.3K	$366.8K	$48.0K
Richard S. GearyEVP, Chief Development Officer	$622.1K	$1.1M	$536.9K	$661.9K	$366.8K	$47.8K
Elizabeth L. HougenEVP, Finance and Chief Financial Officer	$729.8K	$1.5M	$756.6K	$831.9K	$516.8K	$43.0K
Brett P. MoniaChief Executive Officer	$1.1M	$4.3M	$4.1M	$2.4M	$1.4M	$18.0K
Eric SwayzeEVP, Research	$589.0K	$1.1M	$536.9K	$626.7K	$366.8K	$18.0K
Patrick R. O’NeilEVP, Chief Legal Officer and General Counsel	$611.8K	$1.1M	$536.9K	$581.2K	$366.8K	$18.0K

Brett P. Monia · FY 2025

Stock awards$4.3M32%

Performance bonus$2.4M18%

Salary$1.1M8%

Other$5.6M42%

TSR % vs. CEO comp actually paid · 6 fiscal years · Item 402(v) disclosure

TSR

CEO comp

FY20

-6%

$3M

FY21

-50%

$-3M

FY22

-37%

$10M

FY23

-16%

$14M

FY24

-42%

$-3M

FY25

+40%

$43M

CEO total compMedian employeePay ratio (right axis)